Research Assistant
The Wang lab has one opening for a Research Assistant in the Department of Molecular &
Systems Biology at the Geisel School of Medicine at Dartmouth College.
We are looking for highly motivated individuals with an interest in both basic and translational
biomedical research, particularly in cancer epigenetics. We welcome individuals with degrees
in biology, biochemistry, genetics, bioinformatics, and/or computer science.
The Wang lab studies the SWI/SNF (mBAF) family of chromatin remodeling complexes, large multi-subunit complexes that are mutated in more than 20% of human cancers. We have
previously established that SWI/SNF complexes play critical roles in regulating chromatin
structure and gene expression, and that disruption of these roles can create specific
dependencies in numerous cancers. As such, targeting the SWI/SNF subunits that constitute
these dependencies could yield novel cancer therapies. We use cancer cell line models
combined with molecular, biochemical, and bioinformatic approaches such as CRISPR-Cas9 gene editing platform, protein immunoprecipitation coupled with mass-spectrometry, next-generation sequencing such as ChIP-Seq, RNA-seq, ATAC-Seq, Hi-C to research these possibilities. Specifically, we seek to:
1) Understand how the SWI/SNF complex is assembled and how this process controls
targeting of the complex on chromatin
2) Investigate the role of the SWI/SNF complex in controlling chromatin regulatory
elements, particularly enhancers
3) Identify specific cancer dependencies created by SWI/SNF complex mutations and
study their underlying mechanisms
Research Assistant applicants should send their CV to: Xiaofeng.Wang@Dartmouth.edu
Dartmouth College is an equal opportunity/affirmative action employer with a strong commitment to diversity and inclusion. We prohibit discrimination on the basis of race, color, religion, sex, age, national origin, sexual orientation, gender identity or expression, disability, veteran status, marital status, or any other legally protected status. Applications by members of all underrepresented groups are encouraged.