Research Technician - Mancias Lab
Research Technician - Mancias Lab
Dana-Farber Cancer Institute
Boston, MA
The laboratory of Joseph Mancias, MD, PhD at the Dana-Farber Cancer Institute and Harvard Medical School in Boston, MA is inviting applications for a funded Research Technician position to begin as early as March 2020.
The Mancias Lab studies critical aspects of the biology of pancreatic cancer in order to develop novel therapeutic approaches. Particular areas of emphasis are on the role of selective autophagy and iron metabolism in pancreatic cancer molecular pathogenesis (Mancias et al, Nature 2014; Mancias et al, eLife 2015; Santana-Codina et al, Haematologica 2019; Santana-Codina et al, Pharmaceuticals 2018). We are also interested in identifying the biochemical pathways and signaling networks that mediate pancreatic cancer treatment resistance, including to targeted inhibitors, immunotherapy and radiotherapy (Biancur et al, Nature Communications 2017; Santana-Codina et al, bioRxiv 2019; https://www.damonrunyon.org/our-impact/current-projects/scientists/4666).
The lab takes a comprehensive approach to study our questions combining biochemical, quantitative mass spectrometry-based proteomics, CRISPR genetic screens (in vitro and in vivo), cell biological, and mouse modeling techniques.
This individual will be an important member of our research team and will be centrally involved in assisting various research projects utilizing several techniques that are fundamental to the workflow of the Mancias Lab. In addition to the bench-based research, responsibilities will also include some aspects of laboratory management and organization. Training is available in all aspects of experimental research.
For more information on the lab, please visit here: https://manciaslab.dana-farber.org/ and here: https://twitter.com/ManciasLab
Responsibilities:
- Assist in the maintenance of a mouse colony and in vivo experiments such as drug treatments.
- Maintain cell culture and perform drug treatments.
- Perform cellular and molecular experiments on mouse and human cells, including real-time PCR, western blot, microscopy, and mass spectrometry-based quantitative proteomics.
- Contribute to the preparation and presentation of written or oral progress reports concerning studies and assist in publication of results by generating data, proofreading, editing, and contributing ideas.
- Assist with the management and organization of a lab.
Qualifications:
- Bachelor’s degree required with a major in biological sciences preferred
- The candidate should ideally have at least one year of laboratory experience beyond coursework
- Prior experience handling and working directly with mouse models is highly desirable
- Must have excellent communication skills (written and verbal) and be able to keep accurate experimental records
- Ability to analyze information and use logic to address work-related issues and problems
- Must have close attention to detail and consistent work habits
- Ability to work within a team environment
- Must have good time management
For more information, or to apply, please visit: https://careers-dfci.icims.com/jobs/17459/research-technician/job?iis=Social+Networks&iisn=Paula+Conley&iieid=pe1581219926673b2a9f&iispid=88818&mobile=false&width=1903&height=500&bga=true&needsRedirect=false&jan1offset=-300&jun1offset=-240
Note: This is a great position for an individual interested in attending a biomedical graduate school program or medical school (or MD/PhD program). Mentoring for graduate/medical school applications is available through the principal investigator as well as clinical shadowing opportunities. Prior research technicians in this position have gone on to medical school and graduate school and have been first author and/or co-author on peer-reviewed publications by the time they left the laboratory.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.